General Alphonso Knoxx is the head of Cerberus United States Division. He is a Colossus, one of the biggest and mightiest soldiers in Cerberus, and undoubtedly the greatest soldiers of humanity. He wears a special set of Colossus armor, which is made of the same material as Cerberus' destroyer cruisers. Knoxx is a mighty human warrior, and he is over 10 feet tall in armor. He is the undisputed commander of Cerberus' American armed forces, and he answers only to Handsome Jack himself. He is feared by his enemies, and respected by his allies.
General Knoxx served Cerberus for much of his augmented life, fighting across many battlefields to secure victory for Cerberus, and often succeeding in his campaigns. He was such a revered soldier, that when the Highbreed invaded Earth, he was sent to lead the charge against the alien creatures. Unfortunately, he met his end on this very mission, impaled and mutilated to death by the brutal Mogu General, Iron Qon.